Researchers are always testing new ways to treat cancer and improve healthcare. Choosing to participate in a clinical trial is an important personal decision. If you are considering participating in a clinical trial for a cancer therapy, please consult your physician to help you decide if a trial is right for you. After identifying some trial options, another next step is to contact the study research staff, as indicated at the bottom of each trial listing, or you may contact OSI directly at Toll Free: 800-572-1932 or Medical Information, and to ask questions about specific trials.

To learn more about OSI clinical trials that are under way or to find out if a study is enrolling patients in your area, please visit www.clinicaltrials.gov*.

Several resources are available to help patients and their families learn more about cancer clinical trials. One helpful resource is www.CancerTrialsHelp.org*, a non-profit organization that is dedicated to providing the facts about cancer clinical trials, what they are, why they are important and how they work.

The final choice of whether to enter a trial is up to you, but your medical team can help you weigh the options. Here are some questions you may want to ask your doctor:

• Why is this trial important to me? What is it trying to prove?
• Who is sponsoring the trial?
• What are the potential benefits and how do those benefits compare to other treatment options?
• Who can participate in this trial?
• What are the eligibility requirements?
• Who will monitor my care and safety?
• Who will review the information collected during the trial?
• What are the trial's tests and treatments?
• Will I be hospitalized? If so, how often and for how long?
• Will I be able to see my own doctor? Who will be in charge of my care?
• How often will I need to visit a physician's office?
• How long will the trial last?
• How will the trial and its possible side effects affect my daily life? Are there treatments to help alleviate side effects?
• What support will be available for me and my caregivers during the trial? Can I talk to other people in the trial?
• What are my out-of-pocket costs and responsibilities?
• Will my insurance company, Medicaid, or managed care plan cover these costs? Who will help me answer this question?
• What is the long-term follow-up care? Who is providing this care?

Source: www.CancerTrialsHelp.org*

OSI Pharmaceuticals, Inc., believes clinical research should be conducted in an open environment with the objective of allowing physicians and patients to make informed decisions in the selection of available treatment options. The Company’s policy statement regarding the registration of ongoing clinical studies and the disclosure of results from completed clinical studies is available here. This statement reflects what OSI believes is its ethical obligation to ensure such information is available in a timely fashion and to promote transparency in the clinical study process.

All OSI-sponsored clinical studies with efficacy endpoints are registered on a free, publicly accessible, independent website: www.clinicaltrials.gov*.

Citations for publications based on OSI-sponsored, Phase 2, 3, and 4, hypothesis-testing clinical studies for marketed products are available at www.clinicalstudyresults.org*.

* These websites are not endorsed by OSI, and OSI is not responsible for their content.