OSI’s Oncology research strategy is based on an expectation for the future of cancer therapy. Over the coming years, we predict a continued development of the use of oral targeted therapies both as single agents and in combination with other molecular targeted therapies. Oncology research at OSI couples the identification of pharmacodynamic, surrogate, and diagnostic markers to help in monitoring efficacy and selecting sensitive patients during development and commercialization.
Our research organization is focused on the discovery of novel small molecule compounds targeted against the underlying molecular mechanisms of the pathogenesis of cancer. Our strategy is to develop mechanism-based approaches to drug discovery directed at the processes underlying the role of the Epithelial Mesenchymal Transition (EMT) in the development of cancer.

Academic Researchers: For more information on OSI compounds for academic research, click here.

EMT is thought to be a marker of tumor progression, with tumors that express mesenchymal markers having a greater tendency to be invasive and metastasize than those tumors only expressing epithelial markers. Tumors expressing mesenchymal markers are thought to have a worse prognosis than tumors expressing epithelial markers.
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